If you are active, moving fast, you are as warm at -10C as you are inactive at 10C, the heat produced in the core is forcing heat to be dumped into the rest of the body. Depending your mass (slim = fast, fatter= slower) there is a 5-30min lag between moving and its cause on comfort.
The layer system is predominantly about solving this output problem. In a typical hiking situation you have a climbing period, a flat period, and a descent period. Those vary the output significantly and you're wanting to vary the insulation a lot to match. If you don't then you sweat into clothing when hot which then is either evaporating when you don't want it later, or conducting cold into you.
Personally, I try to not go above 3 layers, the 4 layer ideal is faff. My baselayer is to the season and the max output threshold, so seasonally varying between a very thin base t-shirt to a more thicker insulating base, then the midlayer varies to the season of either a fleece or a waterproof insulator, and the last layer is to the season of a hardshell to a synthetic insulator to down.
If I were in English summer, I'd be in a synthetic thin t-shirt, I'd have a fleece and a breathable shell. If I were in a high altitude summer, I'd have a long-sleeve thin top (UV is stronger), a down mid layer and a shell. If I were in a English winter I'd have a Merino base, a waterproof mid and a synthetic outer.
UK has Paramo which does a waterproof mid, USA has to make its own equivalent with fleece+eVent or Powershell, or similar.
I don't know what is a fused toe or any of these toe specific issues.
I have though had periods of broken toes, ankle, legs, wrist, knees, shoulder.
You can flip between cycling and hiking to work around the specific body part problem. Often what makes walking hard tends to not affect cycling so much. Cycling doesn't use toes, you have a rigid shoe plate and its really about the ankle and knee. You can do biking loops in mountainous areas, you can still camp but near roads, you could mountain bike and wild camp. You can let your toes heal, whilst you keep in a good physical condition, and chances are your toes would heal faster if you were generally active and fit.
I live in USA but I was in UK for a few weeks in June/July and I did a Lakes B&B hike/bike week with walking a few days then my feet hurt so I did a bike day. I have also done all-bike trips and all-walking trips.
Work around the problem and keep active, that will tend to minimise the problems.
I have had periods needing to walk with a stick, now don't need to. I broke my shoulder 3 years ago now healed.
I don't see mention of Tarptent, when you include price, robustness and service, its very good. More so for USA than UK though.
I pond hop which is good to avoid the UK population's density to vote in high-taxation politicians with the 20% VAT. From that I find the UK's Paramo wins for cold damp situations, PHD wins for best lightweight down, I got 2 of their bags and a vest, Montbell wins for best value down (Parka), Tarptent wins for best tent (Notch, followed by SS1 and Protrail), Black Diamond for best poles, Inov8 for best lightweight shoes, Montane for best windproofs and trousers, Golite (no more!) for best value pack (Peak and Jam), OMM for best lightweight warmer wet situations.
My most long-lived items are Paramo, they just keep going......
Issue with warm baselayers is if you get active and too hot then you're talking having to strip down to skin to then re-layer backup. 4 layers should be sufficient. Base, fleece, windproof and down / primaloft. A warm baselayer which is fairly porous if you did strip down to base to get most ventilation is Paramo Grid.